Journal of Medicinal Chemistry p. 972 - 978 (1990)
Update date:2022-08-04
Topics:
Nicholas
Wani
Manikumar
Wall
Kohn
Pommier
The total synthesis of the pentacyclic camptothecin analogues 3 and 4 in 11 steps from p-tolualdehyde is described. The overall shape of compound 3 is the same as that of potent, naturally occurring camptothecin (1a). Despite the near spatial identity of
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