Tetrahedron p. 6145 - 6160 (1989)
Update date:2022-07-29
Topics: Termination Undecaprenyl diphosphate Synthase reaction Artificial substrate homologues Novel behavior Prenyl chain elongation Experimental terms here
Ohnuma, Shin-ichi
Ito, Michio
Koyama, Tanetoshi
Ogura, Kyozo
(E)-3-Methyl-3-pentenyl diphosphate acted as an artifical homoallylic substrate in the reaction with several allylic diphosphates catalyzed by undecaprenyl diphosphate synthase of Bacillus subtilis.The synthase reaction with the artificial substrate proceeded in the same stereochemical manner as that with the natural homoallylic substrate, isopentenyl diphosphate, but it had a full stop at the stage where a single condensation of the C6-homologue with an allylic primer is completed to form a chiral prenyl diphosphate with an extra methyl group at the 4-position.Allylic diphosphates that each have an extra methyl group at the 4-position were not accepted as substrates for this enzyme even when isopentenyl diphosphate was the homoallylic substrate.
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