An efficient synthesis of 6-nitro-and 6-amino-3H-imidazo[4,5-b ]pyridines by cyclocondensation of 1-substituted 1H-imidazol-5-amines with 3-nitro-4H-chromen-4-one

Article abstract of DOI:10.1055/s-0030-1258538

The reaction of 3-nitro-4H-chromen-4-one with in situ generated 1-substituted 5-amino-1H-imidazoles affords a set of 1-substituted 6-nitro-3H-imidazo[4,5-b]pyridines which represent potential adenosine deaminase (ADA) inhibitors. Reduction of the nitro group results in the formation of the corresponding 6-amino-3H-imidazo[4,5-b]pyridines. Georg Thieme Verlag Stuttgart - New York.