Total synthesis of WS9326A, a potent tachykinin antagonist from Streptomyces violaceoniger

DOI: 10.1248/cpb.45.236

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 236 - 242 (1997)

Update date:2022-08-04

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Authors:

Shigematsu, Nobuharu

Kayakiri, Natsuko

Okada, Satoshi

Tanaka, Hirokazu

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Article abstract of DOI:10.1248/cpb.45.236

Total synthesis of the cyclic peptide lactone WS9326A, a potent tachykinin antagonist isolated from Streptomyces violaceoniger strain 9326, has been achieved via Cbz-Thr(Boc-allo-Thr-Asn-Ser(Bzl))-(E)ΔMeTyr-Leu-D- Phe-OTce, which was cyclized (Phe and all

Full text of DOI:10.1248/cpb.45.236

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