Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome

DOI: 10.1016/j.bmcl.2010.10.001

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7488 - 7492 (2010)

Update date:2022-08-05

Topics:

Authors:

Stathakis, Christos I.

Mavridis, Ioannis

Kythreoti, Georgia

Papakyriakou, Athanasios

Katsoulis, Ioannis A.

Cottin, Thomas

Anastasopoulou, Panoula

Vourloumis, Dionisios

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Article abstract of DOI:10.1016/j.bmcl.2010.10.001

Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and exten

Full text of DOI:10.1016/j.bmcl.2010.10.001

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