Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-methyl-D-aspartate antagonists

DOI: 10.1248/cpb.44.95

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Chemical and Pharmaceutical Bulletin p. 95 - 102 (1996)

Update date:2022-08-05

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Authors:

Ohkubo, Mitsuru

Kuno, Atsushi

Katsuta, Kiyotaka

Ueda, Yoshiko

Shirakawa, Kiyoharu

Nakanishi, Hajime

Nakanishi, Isao

Kinoshita, Takayoshi

Takasugi, Hisashi

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Article abstract of DOI:10.1248/cpb.44.95

A series of 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for anticonvulsant activity against intracerebro-ventriculas (i.c.v.) N-methyl-D-aspartate (NMDA)-induced seizures in mice. Among these compounds, (+)-1-methyl-1-phenyl-

Full text of DOI:10.1248/cpb.44.95

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