Journal of Medicinal Chemistry p. 1210 - 1220 (1993)
Update date:2022-08-03
Topics: Structure-activity relationships (SAR) Clinical Development Biological Activity Phosphodiesterase Inhibition Pharmacokinetics and Safety
Tulshian, Deen
Czarniecki, Michael
Doll, Ronald J.
Ahn, Ho-Sam
Synthetic analogs of the natural product griseolic acid in which a guanine base is substituted for the adenine have been prepared.The best of these compounds inhibits a cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase preparation with an IC50
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