Synthesis and Phosphodiesterase Activity of Carboxylic Acid Mimetics of Cyclic Guanosine 3',5'-Monophosphate

DOI: 10.1021/jm00061a012

Source and publish data:

Journal of Medicinal Chemistry p. 1210 - 1220 (1993)

Update date:2022-08-03

Topics: Structure-activity relationships (SAR) Clinical Development Biological Activity Phosphodiesterase Inhibition Pharmacokinetics and Safety

Authors:

Tulshian, Deen

Czarniecki, Michael

Doll, Ronald J.

Ahn, Ho-Sam

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00061a012

Synthetic analogs of the natural product griseolic acid in which a guanine base is substituted for the adenine have been prepared.The best of these compounds inhibits a cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase preparation with an IC50

Full text of DOI:10.1021/jm00061a012

Products guided by the article

Product name:2H-Cyclopenta[b]furan-2-carbonitrile,5-(acetyloxy)hexahydro-(9CI)

Cas No:126261-33-4

R&D Labs maybe for 126261-33-4

Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong
Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District
Deltachem(QingDao)Co.,Ltd.

Contact:+8618766299236

Address:ROOM808, BUILDING2,NO.230 SHEN ZHEN ROAD, LAOSHAN DISTRICT

Relevant to this article

Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

Doi:10.1016/j.tet.2010.10.055
(2010)
A kinetically controlled direct aldol addition of α-chloro thioesters via soft enolization

Doi:10.1016/j.tetlet.2016.11.010
(2017)
Organocatalyzed carboxylative cyclization of propargylic amides with atmospheric CO₂ towards oxazolidine-2,4-diones

Doi:10.1039/c8gc03929a
(2019)
Stereoselective construction of a steroid 5α,7α-oxymethylene derivative and its use in the synthesis of eplerenone

Doi:10.1016/j.steroids.2010.08.009
(2011)
Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines

Doi:10.1134/S107042801011014X
(2010)
Norbornadiene-bridged diarylethenes and their conversion into turn-off fluorescent photoswitches

Doi:10.1039/d0cc02210a
(2020)

Article Doi