Three Routes to the Critical C16'-C14' Parf Relative Stereochemistry of Vinblastine. Syntheses of 20'-Desethyl-20'-deoxyvinblastine and 20'-Desethyl-20'-deoxyvincovaline

DOI: 10.1021/jo00228a035

Source and publish data:

Journal of Organic Chemistry p. 4340 - 4349 (1987)

Update date:2022-09-26

Topics: Syntheses Experimental Vinblastine Relative Stereochemistry

Authors:

Kuehne, M. E.

Zebovitz, T. C.

Bornmann, W. G.

Marko, I.

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Article abstract of DOI:10.1021/jo00228a035

Coupling reactions of vindoline (2) with the racemic chloro imine derivative 8 of 14-epi-D-secodesethylvincadifformine (7) resulted in a selective high yield formation of the C16'-C14' parf (vinblastine type) relative configuration of the coupling product

Full text of DOI:10.1021/jo00228a035

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