Directed Lithiation of Chlorobenzenes. Regioselectivity and Application to a Short Synthesis of Benzocyclobutenes

DOI: 10.1021/jo00298a045

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Journal of Organic Chemistry p. 3622 - 3627 (1990)

Update date:2022-09-26

Topics:: Authors:

Iwao, Masatomo

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Article abstract of DOI:10.1021/jo00298a045

Chlorobenzene and its OMe, OSiMe2-t-Bu, and Cl derivatives 1 were lithiated with high regioselectivity ortho to chlorine by treatment with sec-BuLi in THF at -105 deg C without complications due to benzyne formation.The lithio species thus generated under

Full text of DOI:10.1021/jo00298a045

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Directed Lithiation of Chlorobenzenes. Regioselectivity and Application to a Short Synthesis of Benzocyclobutenes

DOI: 10.1021/jo00298a045

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jo00298a045

Full text of DOI:10.1021/jo00298a045

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