Bioorganic and Medicinal Chemistry Letters p. 836 - 840 (2011)
Update date:2022-08-04
Topics:
Sielaff, Frank
Than, Manuel E.
Bevec, Dorian
Lindberg, Iris
Steinmetzer, Torsten
A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with Ki values of 0.46 and 0.59 μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue,
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