Kinetic resolution of racemic 2-substituted cyclohexanones by enantioselective deprotonation

DOI: 10.1016/S0040-4039(01)89015-8

Source and publish data:

Tetrahedron Letters p. 6537 - 6540 (1989)

Update date:2022-07-29

Topics:

Authors:

Kim Kim

Kawasaki

Nakajima

Koga Koga

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Article abstract of DOI:10.1016/S0040-4039(01)89015-8

Incomplete deprotonation of racemic 2-substituted cyclohexanones (dl-4) by chiral lithium amides (2) in the presence of trimethylsilyl chloride was found to give the corresponding trimethylsilyl enol ethers (5) and the unreacted ketones (4) in reasonably high enantiomeric excesses.

Full text of DOI:10.1016/S0040-4039(01)89015-8

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