Oxazolophanes as masked cyclopeptide alkaloid equivalents: Cyclic peptide chemistry without peptide couplings

Article abstract of DOI:10.1021/ja00175a039

Synthetic studies on the preparation of heteroatom-substituted, novel [3.3]oxazolophanes as precursors to the 14-membered ring system characteristic of the cyclopeptide alkaloids are reported. Simpler model systems are discussed, as is the successful form