Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins

DOI: 10.1021/jm00171a030

Source and publish data:

Journal of Medicinal Chemistry p. 2529 - 2535 (1990)

Update date:2022-09-26

Topics:

Authors:

Shah Shah

Brause Brause

Chandler

Finke Finke

Ashe Ashe

Weston Weston

Knight Knight

Maycock Maycock

Doherty Doherty

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Article abstract of DOI:10.1021/jm00171a030

Several 3'-substituted cephalosporin sulfones were synthesized from 3-(hydroxymethyl)cephalosporin, which was prepared by Ti(OiPr)₄ hydrolysis of the corresponding acetate. A method was also developed to prepare a 3-vinylcephalosporin. Some of

Full text of DOI:10.1021/jm00171a030

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