Synthesis of new 2-, 3-, and 4-substituted azidoquinolines: Inhibitors of human blood platelet aggregation in vitro

Article abstract of DOI:10.1016/0223-5234(90)90022-U

A series of 2-, 3- and 4-substituted azidoquinoline derivatives were synthesized and tested for their ability to inhibit human platelet aggregation in vitro triggered by adenosine diphosphate (15 μM), collagen (5 μg/ml), platelet activating factor (10 μM), or the stable prostaglandin H₂ mimetic, U46619 (4 μM). The most active compounds (IC₅₀ 2.5-68.3 μM) were the geminal 3,3-diazides (4f and 4g) and the 4-azido-3-nitroquinolines (6f and 6g).