1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 2. Synthesis, Biological Properties and Molecular Modeling of Hydroxyethylene Isostere Derivatives

DOI: 10.1021/jm00171a006

Source and publish data:

Journal of Medicinal Chemistry p. 2335 - 2342 (1990)

Update date:2022-09-26

Topics:

Authors:

Bradbury, Robert H.

Major, John S.

Oldham, Alec A.

Rivett, Janet E.

Roberts, David A.

et al. et al.

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Article abstract of DOI:10.1021/jm00171a006

A series of inhibitors of human renin have been synthesized, derived from combination of a 2-(8-propyl-6-pyridin-3-yl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)-3-pyridin-3-ylpropionic acid moiety 6c with the hydroxyethylene isostere of the scissile amide bond (2

Full text of DOI:10.1021/jm00171a006

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