OXADIAZOLES WITH NF2-CONTAINING SUBSTITUENTS

Article abstract of DOI:10.1016/S0022-1139(00)82383-0

Oxalyl chloride was reacted with sodium-5-(difluoroamino)-difluoromethyltetrazolate or sodium-5-pentafluoroethyltetrazolate to form f = NF2CF2 (7)>, and with F2NCF2C(NH2)=NOH to give 2 (5) which may be dehydrated to the 1,2,4-oxadiazole (6).Both sodium salts can be reacted with perfluoroacyl acid chlorides to form 2,5-disubstituted 1,3,4-oxadiazoles, where R_f'=NF2CF2 and R_f = CF3 (8), C2F5 (9) or C3F7 (10); R_f'= C2F5 and R_f = CF3 (11) or C2F5 (12).