Chemical and Pharmaceutical Bulletin p. 96 - 101 (1992)
Update date:2022-08-05
Topics:
Marui
Itoh
Kozai
Sudo
Kishimoto
The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis induced by basic fibroblast growth factor in the rat corneal micropocket assay and the growth of vascular endothelial cells in vitro. Among them, compound 2 (AGM-1470) was found to show the most potent inhibitory effect on the growth of vascular endothelial cells and was selected from this series as a candidate for further development.
View MoreJiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Hebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Taizhou volsen chemical Co., Ltd
website:http://www.volsenchem.com
Contact:+86-576-88869393
Address:Jiaojiang District, Taizhou, Zhejiang, China.
Wuxi Zuping Food Science And Technology Co.,LTD.
Contact:+86-510-87210822
Address:Guanlin town
jintan yufan Medicine Raw materials Co.,Ltd.(expird)
Contact:86-519-82808282
Address:6th,Jincheng Huangzhuang
Doi:10.1016/j.tet.2011.01.090
(2011)Doi:10.1016/j.jfluchem.2012.05.010
(2012)Doi:10.1016/S0040-4039(01)81422-2
(1984)Doi:10.1002/jhet.523
(2011)Doi:10.1248/cpb.38.389
(1990)Doi:10.1016/j.ejmech.2011.01.062
(2011)
