Angewandte Chemie - International Edition p. 6863 - 6867 (2018)
Update date:2022-07-31
Topics:
Xu, Feng
Kosjek, Birgit
Cabirol, Fabien L.
Chen, Haibin
Desmond, Richard
Park, Jeonghan
Gohel, Anupam P.
Collier, Steven J.
Smith, Derek J.
Liu, Zhuqing
Janey, Jacob M.
Chung, John Y. L.
Alvizo, Oscar
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high-pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.
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