Stereoselective Oxidative Spiroketalization of a C-Arylglucal Derived from Palladium-Catalyzed Coupling. Synthesis of the C-Arylglucoside Spiroketal Nucleus of the Papulacandins

Article abstract of DOI:10.1021/jo00310a004

The synthesis of the C-arylglucoside tricyclic spiroketal nucleus of the papulacandins 5b was achieved utilizing two key steps, namely the palladium-catalyzed coupling of the aryl bromide 6 and the stannyl glucal 2 and stereoselective oxidative spiroketal