Journal of Organic Chemistry p. 5867 - 5877 (1990)
Update date:2022-08-02
Topics:
Amsberry, Kent L.
Borchardt, Ronald T.
The lactoniaztion of two hydroxy amides - 4-methoxyaniline 3-(2'-hydroxyphenyl)-3,3-dimethylpropionic acid amide (2b) and 4-methoxyaniline 3-(2'-hydroxy-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid amide (3b) - was studied over a pH range of 1-8.Due to the slowness of its reaction, a third hydroxy amide - 4-methoxyaniline 3-(2'-hydroxyphenyl)propionic acid amide (1b) - was investigated only at pH values of 7.5 and 10.The lactonization of 2b and 3b, which was found to be subject to general catalysis by buffer components, was observed to be catalyzed concurrently but not concertedly by both the acidic and basic forms of the buffer.The buffer-independent pH rate profiles for the lactonization of 2b and 3b were found to obey the equation k0 = kH+
Contact:+86-21-61318535
Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
Lanling Hongchuang Flame Retardant Co., Ltd.
Contact:+86-531-68858132
Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Jinzhou Jiutai Pharmaceutical Co.,Ltd
Contact:+86-0416-5179890
Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Shijiazhuang Sdyano Fine Chemical Co., Ltd
Contact:+86-311-89830448
Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Doi:10.1016/0022-328X(90)85417-W
(1990)Doi:10.1016/0008-6215(93)87014-J
(1993)Doi:10.1246/cl.1990.1411
(1990)Doi:10.1248/cpb.38.1781
(1990)Doi:10.1002/jms.1575
(2009)Doi:10.1248/cpb.39.3215
(1991)