Stereocontrolled ring-opening of a hindered sulfamidate with nitrogen-containing aromatic heterocycles: Synthesis of chiral quaternary imidazole derivatives

Article abstract of DOI:10.1021/jo200479y

This paper explores the role of a hindered cyclic sulfamidate derived from α-methylisoserine as an electrophile in a nucleophilic displacement reaction with nitrogen-containing aromatic heterocycles. Several imidazoles and pyrazole were tested as nucleoph