Synthesis and antiarrhythmic activity of α-[(Diarylmethoxy)methyl]-1-piperidineethanols

DOI: 10.1021/jm00105a002

Source and publish data:

Journal of Medicinal Chemistry p. 7 - 12 (1991)

Update date:2022-08-02

Topics:

Authors:

Hoefle Hoefle

Blouin Blouin

Fleming Fleming

Hastings

Hinkley Hinkley

Mertz Mertz

Steffe Steffe

Stratton

Werbel Werbel

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Article abstract of DOI:10.1021/jm00105a002

A series of α-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the best antiar

Full text of DOI:10.1021/jm00105a002

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