Synthesis and biological activity of (S)-2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A) derivatives

DOI: 10.1248/cpb.39.1199

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1199 - 1212 (1991)

Update date:2022-09-26

Topics:

Authors:

Tamura Tamura

Matsushita

Iwama Iwama

Harada Harada

Kishimoto

Itoh Itoh

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Article abstract of DOI:10.1248/cpb.39.1199

(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the structure

Full text of DOI:10.1248/cpb.39.1199

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Product name:(S)-2-Benzyloxycarbonylamino-3-[(S)-2-tert-butoxycarbonylamino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-propionic acid methyl ester

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