CONFORMATIONALLY RESTRICTED LEUKOTRIENE ANTAGONISTS. STEREOSELECTIVE SYNTHESIS OF SOME LEUKOTRIENE D4 ANALOGS

DOI: 10.1016/S0040-4020(01)86751-X

Source and publish data:

Tetrahedron p. 4155 - 4160 (1990)

Update date:2022-08-05

Topics:

Authors:

Sabol, Jeffrey S.

Weintraub, Philip M.

Gieske, Thomas H.

Cregge, Robert J.

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Article abstract of DOI:10.1016/S0040-4020(01)86751-X

The stereocontrolled synthesis of conformationally restricted LTD₄ analogs 2a, b is described.Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9.Stereocontrolled elaboration of each epoxide to final product invo

Full text of DOI:10.1016/S0040-4020(01)86751-X

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