Synthesis and characterization of enantiomerically pure cis- and trans-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxides as acetylcholine mimetics and inhibitors of acetylcholinesterase

Article abstract of DOI:10.1002/hlca.201000457

The title compounds, the P(3)-axially and P(3)-equatorially substituted cis- and trans-configured 9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxides (=9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides=7-benzyl-2-fluorohexah