Amino acids as precursors to indolizidine alkaloids

Article abstract of DOI:10.1016/S0040-4039(00)97933-4

Enantiocontrolled synthesis of indolizidine alkaloids δ-coniceine [(-)-(R)-octahydroindolizine] and (+)-(1S, 8aS)-1-hydroxyindolizidine, the biosynthetic precursor of slaframine, have been achieved through a condensation of L-prolinal and 3R,2S-hydroxypro