Discovery of intestinal targeted TGR5 agonists for the treatment of type 2 diabetes

DOI: 10.1021/jm500829b

Source and publish data:

Journal of Medicinal Chemistry p. 3315 - 3328 (2015)

Update date:2022-07-29

Topics:

Authors:

Duan, Hongliang

Ning, Mengmeng

Zou, Qingan

Ye, Yangliang

Feng, Ying

Zhang, Lina

Leng, Ying

Shen, Jianhua

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Article abstract of DOI:10.1021/jm500829b

Activation of TGR5 stimulates intestinal glucagon-like peptide-1 (GLP-1) release, but activation of the receptors in gallbladder and heart has been shown to cause severe on-target side effects. A series of low-absorbed TGR5 agonists was prepared by modify

Full text of DOI:10.1021/jm500829b

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