SYNTHESIS OF REGULAR POLYPEPTIDES INCLUDING POLYFUNCTIONAL AMINO ACIDS

Article abstract of DOI:10.1007/BF00581603

Polypeptides of regular structure with the sequences His-Glu, Ser-Glu, Try-Glu, His-Tyr, and Glu-His have been synthesized by the 2,4,5-trichlorophenyl ester method.Polymerization was carried out in dimethyl sulfoxide and dimethylformamide.The polymers were purified by dialysis against water.In the process of synthesizing the monomers, the α-amino groups of the acids were protected by ortho-nitrophenylsulfenyl (o-NPS-), benzyloxycarbonyl (Z-), and tert-butoxycarbonyl (t-BOC-) groups.The imidazole group of histidine was Z-protected, and the γ-hydroxy group of glutamic acid and the phenolic OH group of tyrosine were benzyl-protected (Bzl-).