Journal of the Chemical Society. Chemical communications p. 1026 - 1028 (1987)
Update date:2022-08-03
Topics:
Smith, Amos B.
Hale, Karl J.
Vaccaro, Henry A.
The first total synthesis of the important antitumor glycoside (-)-phyllanthostatin-1 (1) is described; the key steps include a regioselective Koenigs-Knorr reaction to establish the 1,2-O-linkage in disaccharide (6) and a stereoselective triphenylphosphine-di-isopropyl azodicarboxylate (TPP-DIAD) glycosidation of hemiacetal (12) with aglycone (15).
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