Novel and Selective Enzymatic Hydrolysis of γ-Esters of Dimethyl α-Dehydroglutamate with α-Chymotrypsin A

Article abstract of DOI:10.1246/cl.1990.2089

Selective enzymatic hydrolysis of γ-ester of Cbz-ΔGlu(OMe)-OMe with α-chymotrypsin at pH 9 was readily achieved to give the corresponding α-half ester (Cbz-ΔGlu-OMe) along with a small amount of Cbz-ΔGlu(OMe)-OH and Cbz-ΔGlu-OH.