Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity

Article abstract of DOI:10.1021/jm00079a019

The synthesis and evaluation of some 2'- and 7-amino acid derivatives of taxol (1) are reported. Reaction of taxol with N-protected amino acids gave 2'-N-protected amino acid esters of taxol. However, deprotection of the amino group and subsequent isolati