Journal of Medicinal Chemistry p. 1545 - 1552 (1991)
Update date:2022-07-29
Topics:
Bellamy
Chazan
Dodey
Dutartre
Ou
Pascal
Robin
A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.
View MoreClickChem Technology Co., Limited
Contact:+86-0310-6519966/0531-52893837
Address:No.750 Shunhua Road, High-Tech Zone, Jinan city, Shandong China
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
zhangjiagang bonded areas banggao co;ltd
website:http://www.shunchangchem.com
Contact:0086-13921972933
Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
HK Vast Medicinal Chemistry Int'l Group Limited(expird)
website:http://www.hkvast.com/
Contact:+86-15000309979
Address:NO.6,Lane 108,Qinzhou Road,Xuhui District,Shanghai
Doi:10.1039/c4nj02319f
(2015)Doi:10.1016/j.mencom.2011.07.004
(2011)Doi:10.1248/cpb.45.327
(1997)Doi:10.1016/0040-4039(91)80856-2
(1991)Doi:10.1021/ol2020384
(2011)Doi:10.1016/j.jorganchem.2011.06.019
(2011)
