An efficient asymmetric synthesis of substituted phenyl glycidic esters

Article abstract of DOI:10.1016/S0040-4039(00)97101-6

Chiral substituted glycidic esters have been prepared from their corresponding chalcones via a two step procedure consisting of an asymmetric epoxidation mediated by a poly-L-leucine polymer, followed by a previously unreported Baeyer-Villiger oxidation. The regioselectivity of this latter procedure was found to depend on the aryl substituent.