Tetrahedron Letters p. 5779 - 5780 (1990)
Update date:2022-08-02
Topics:
Tarnchompoo, Bongkoch
Thebtaranonth, Chachanat
Thebtaranonth, Yodhathai
Direct deprotonation of 1-(N,N-dimethylaminomethyl)2-methylimidazole 4 by n-butyllithium yields anion 5 which can readily undergo alkylation reactions.This finding provides immediate access to 2-(2-arylethyl)imidazoles, 1, which are clumsy to prepare by other methods.
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(2017)
