An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Article abstract of DOI:10.1016/S0040-4039(00)98026-2

An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reac