Quantitative metalations of 2-substituted 1,3-dithianes at -78°C using n-BuLi/Na-O-t-Bu

DOI: 10.1016/S0040-4039(00)88539-1

Source and publish data:

Tetrahedron Letters p. 7261 - 7264 (1990)

Update date:2022-08-04

Topics:

Authors:

Lipshutz

Garcia Garcia

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)88539-1

Substituted dithianes can be metalated rapidly at -78°C in a virtually quantitative fashion using n-BuLi and Na-O-t-Bu in THF. Subsequent introduction of an electrophile affords fully substituted masked ketone equivalents.

Full text of DOI:10.1016/S0040-4039(00)88539-1

Products guided by the article

Product name:C₁₄H₁₉⁽²⁾HO₂S₂

Cas No:133031-66-0

R&D Labs maybe for 133031-66-0

Wuxi Zuping Food Science And Technology Co.,LTD.

Contact:+86-510-87210822

Address:Guanlin town
Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
NanJing Rate Biochemicals CO., LTD

Contact:+86-25-84931986

Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China
Jiaxing Carry Bio-Chem Technology Co.,Ltd

website:http://www.carrybiotech.com

Contact:0573-82788958

Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China

Relevant to this article

The Preparation of (R)- and (S)-(E)-But-2-enyl-t-butylphenylphosphine Oxides and their Enantiospecific Conversion into Enantiomeric Hydrindenones related to Vitamin D

Doi:10.1039/c39910000058
(1991)
First microwave-assisted synthesis of an electron-rich phosphane and its coordination chemistry with platinum(II) and palladium(II)

Doi:10.1016/j.ica.2011.05.020
(2011)
Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4- substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents

Doi:10.1007/s00044-011-9708-z
(2012)
Pd-Catalyzed C4-Olefination of Oxazoles via C-H Bond Activation: Divergent Synthesis of Functionalized Amino Alcohol and Amino Acid Derivatives

Doi:10.1021/ol201865h
(2011)
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: Discovery, synthesis, and characterization of their binding mode by protein crystallography

Doi:10.1021/jm200312v
(2011)
Stereocontrolled derivatization of 3-methoxyestra-1,3,5(10), n-tetraenes via lewis acid promoted prins reactions, (n=7; 8(9))

Doi:10.1016/S0040-4039(00)74873-8
(1991)

Article Doi