Quantitative metalations of 2-substituted 1,3-dithianes at -78°C using n-BuLi/Na-O-t-Bu

DOI: 10.1016/S0040-4039(00)88539-1

Source and publish data:

Tetrahedron Letters p. 7261 - 7264 (1990)

Update date:2022-08-04

Topics:

Authors:

Lipshutz

Garcia Garcia

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Article abstract of DOI:10.1016/S0040-4039(00)88539-1

Substituted dithianes can be metalated rapidly at -78°C in a virtually quantitative fashion using n-BuLi and Na-O-t-Bu in THF. Subsequent introduction of an electrophile affords fully substituted masked ketone equivalents.

Full text of DOI:10.1016/S0040-4039(00)88539-1

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