Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease

Article abstract of DOI:10.1016/S0960-894X(99)00049-9

A series of azapeptides was prepared and assessed as inhibitors of the human rhinovirus 3C protease. Boc-VLFaQ-OPh was a slow-turnover substrate that gave transient (ca. 1-2 h) inhibition as it underwent hydrolysis. Boc- VLFaG-OPh gave very slow but essen