Synthesis and pharmacological evaluation of 4,4a-dihydro-5H-benzopyranopyridazin-3-(2H)-ones bioisosters of antihypertensive and antithrombotic benzocinnolinones

DOI: 10.1016/0223-5234(90)90194-8

Source and publish data:

European Journal of Medicinal Chemistry p. 749 - 756 (1990)

Update date:2022-08-03

Topics:

Authors:

Cignarella, G

Barlocco, D

Curzu, M M

Pinna, G A

Cazzulani, P

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(90)90194-8

A series of 4,4a-dihydro-5H-<1>benzopyrano<4,3-c>pyridazin-3-(2H)-ones (2a-h), have been prepared and evaluated for their pharmacological profile as antihypertensive and antithrombotic agents.Compounds 2 were ineffective in lowering the blood pressure of

Full text of DOI:10.1016/0223-5234(90)90194-8

Products guided by the article

Product name:2'-hydroxy-4'-acetamido-3-benzoyl-propionic acid

Cas No:133414-38-7

R&D Labs maybe for 133414-38-7

Hawks Chemical

Contact:+44 (0)161 367 9441

Address:
shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Lanzhou huibang biological chemical technology Co., LTD

Contact:0931-7843964

Address:NO.2011,Yannan Road,Chengguan,
Yantai Derun Liquid Crystal Materials Co. Ltd.

website:http://www.ytderun.com

Contact:86-535-6300169

Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI

Relevant to this article

A Practical synthesis of novel Rho-kinase inhibitor, (S)-4-fluoro-5-(2- methyl-1,4-diazepan-1-ylsulfonyl)-isoquinoline

Doi:10.3987/COM-11-12230
(2011)
Palladium-catalyzed 1,4-addition of diarylphosphines to α,β-unsaturated N-acylpyrroles

Doi:10.1039/c1cc13785a
(2011)
Synthesis, characterisation, and biological activity of three new amide prodrugs of lamotrigine with reduced hepatotoxicity

Doi:10.2478/s11696-010-0094-7
(2011)
Redox-active π-conjugated polymer nanotubes with viologen for encapsulation and release of fluorescent dye in the nanospace

Doi:10.1039/c1cc13853g
(2011)
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Doi:10.1021/acs.jmedchem.1c00735
(2021)
Rhodium(I)-catalyzed cycloisomerization of nitrogen-tethered indoles and alkylidenecyclopropanes: Convenient access to polycyclic indole derivatives

Doi:10.1002/chem.201302331
(2013)

Article Doi