Synthesis and pharmacological evaluation of 4,4a-dihydro-5H-benzopyranopyridazin-3-(2H)-ones bioisosters of antihypertensive and antithrombotic benzocinnolinones

Article abstract of DOI:10.1016/0223-5234(90)90194-8

A series of 4,4a-dihydro-5H-<1>benzopyrano<4,3-c>pyridazin-3-(2H)-ones (2a-h), have been prepared and evaluated for their pharmacological profile as antihypertensive and antithrombotic agents.Compounds 2 were ineffective in lowering the blood pressure of