On the Remarkable Propensity for Carbon-Carbon Bond Cleavage Reactions in the C8-C10 Region of FK-506

DOI: 10.1021/jo00008a055

Source and publish data:

Journal of Organic Chemistry p. 2900 - 2907 (1991)

Update date:2022-08-05

Topics:

Authors:

Fisher, Matthew J.

Chow, Ken

Villalobos, Anabella

Danishefsky, Samuel J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00008a055

It has been deduced from a series of transformations that formation of a tetrahedral intermediate at C9 in FK-506 occasions fragmentation of the C9-C10 bond by a retro-Claisen-like pathway or the C9-C8 bond by a benzilic acid type rearrangement.Reduction

Full text of DOI:10.1021/jo00008a055

Products guided by the article

Product name:C₄₅H₇₁NO₁₂

Cas No:133577-25-0

R&D Labs maybe for 133577-25-0

Shanghai Gsyn Chemical Co.,Ltd.

Contact:86-021-67158290

Address:86-021-67158291
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Jiangsu Mingchem Corporation

Contact:0519-85170101-802

Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
CHINA MEHECO CORPORATION

Contact:+86-10-67147360/67107388

Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China

Relevant to this article

Reactions of imidoyl isoselenocyanates with aromatic 2-amino N-heterocycles and 1-methyl-1H-imidazole

Doi:10.1002/hlca.201100230
(2011)
Synthesis of N-(5-(Substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2, 4-triazol-4-amine from 4-Amino-4H-1,2,4-triazole

Doi:10.1155/2011/658708
(2011)
Solvent-induced anomeric diastereoselectivity switching using a single glycosyl donor

Doi:10.1016/j.carres.2011.06.026
(2011)
Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

Doi:10.1021/jo201303x
(2011)
Synthesis and hole transport properties of highly soluble pyrene-based discotic liquid crystals with trialkylsilylethynyl groups

Doi:10.1080/15421406.2011.536485
(2011)
Photomodulation of the proton affinity and acid gated photochromism of a novel dimethylaminophenyl thiazole diarylethene

Doi:10.1016/j.dyepig.2011.05.006
(2012)

Article Doi