On the Remarkable Propensity for Carbon-Carbon Bond Cleavage Reactions in the C8-C10 Region of FK-506

DOI: 10.1021/jo00008a055

Source and publish data:

Journal of Organic Chemistry p. 2900 - 2907 (1991)

Update date:2022-08-05

Topics:

Authors:

Fisher, Matthew J.

Chow, Ken

Villalobos, Anabella

Danishefsky, Samuel J.

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Article abstract of DOI:10.1021/jo00008a055

It has been deduced from a series of transformations that formation of a tetrahedral intermediate at C9 in FK-506 occasions fragmentation of the C9-C10 bond by a retro-Claisen-like pathway or the C9-C8 bond by a benzilic acid type rearrangement.Reduction

Full text of DOI:10.1021/jo00008a055

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