Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin

DOI: 10.1016/0223-5234(91)90058-U

Source and publish data:

European Journal of Medicinal Chemistry p. 261 - 271 (1991)

Update date:2022-07-29

Topics: Synthesis NMR spectroscopy X-ray crystallography Biological Evaluation Animal Models Cell culture assays Netropsin

Authors:

Debart Debart

Gosselin

Rayner Rayner

Le Ber Le Ber

Auclair Auclair

Balzarini

De Clercq

Paoletti

Imbach Imbach

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Article abstract of DOI:10.1016/0223-5234(91)90058-U

A series of oligo-meta-benzamides structurally related to the natural agent netropsin have been synthesized. Their binding constants to double-stranded polynucleotides as well as their cytostatic activity against tumor cell lines and their in vitro activi

Full text of DOI:10.1016/0223-5234(91)90058-U

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