Synlett p. 1831 - 1834 (2011)
Update date:2022-08-05
Topics:
Pace, Vittorio
Hoyos, Pilar
Sinisterra, José Vicente
Alcántara, Andrés R.
Holzer, Wolfgang
The regioselective synthesis of several aminoepoxides has been achieved without observing any trace of azetidinols, which are usually reported as the exclusive reaction products when aminohalohydrins are treated with bases. The use of the mild supported base KF-Celite in refluxing acetonitrile is crucial for modulating the excellent regioselectivity observed. Georg Thieme Verlag Stuttgart . New York.
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