Studies on Enantioselective Addition of Chiral Titanium Reagents to Aromatic Aldehydes

Article abstract of DOI:10.1055/s-1989-27227

A series of substituted chiral benzhydrols were synthesized by reaction of aromatic aldehydes with the chiral intermediates formed from chiral titanates and arylmagnesium halides.The effect of substituents on the enantioselectivity of the reaction is studied.The reactions are carried out with two different chiral intermediates using two different procedures.