Synthesis of 2,5-Substituted Piperidines and Their Bicyclic Piperazine Analogues: The 2,7-Substituted Octahydro-2H-pyridopyrazines

DOI: 10.1021/jo00017a036

Source and publish data:

Journal of Organic Chemistry p. 5192 - 5196 (1991)

Update date:2022-07-30

Topics:

Authors:

Compernolle, Frans

Saleh, M.-Ashty

Toppet, Suzanne

Hoornaert, Georges

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Article abstract of DOI:10.1021/jo00017a036

Partial and complete reduction of the key compound 1-benzyl-5-(ethylenedioxy)-2-piperidinecarbonitrile (1) was applied to generate the corresponding aldehyde 2 and primary amine 3.These were transformed into bicyclic 7-(ethylenedioxy)-2(R)-octahydro-2H-py

Full text of DOI:10.1021/jo00017a036

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