Synthesis of 2,5-Substituted Piperidines and Their Bicyclic Piperazine Analogues: The 2,7-Substituted Octahydro-2H-pyridopyrazines

Article abstract of DOI:10.1021/jo00017a036

Partial and complete reduction of the key compound 1-benzyl-5-(ethylenedioxy)-2-piperidinecarbonitrile (1) was applied to generate the corresponding aldehyde 2 and primary amine 3.These were transformed into bicyclic 7-(ethylenedioxy)-2(R)-octahydro-2H-py