Alkylation of an imidazolidine enaminoester: A new sequence for the c(α)-alkylation of 4,5-dihydroimidazoles

DOI: 10.1016/S0040-4020(97)00752-7

Source and publish data:

Tetrahedron p. 11781 - 11790 (1997)

Update date:2022-07-29

Topics:

Authors:

Jones, Raymond C. F.

Patel, Pravin

Hirst, Simon C.

Turner, Ian

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Article abstract of DOI:10.1016/S0040-4020(97)00752-7

1-Benzyl-2-(ethoxycarbonyllmethylene)-2,3,4,5-tetrahydroimidazole undergoes preferred C-alkylation with halogenonakanes, dihalogenoalkanes and epoxides: subsequent removal of of the ethoxycarbonyl group provides a new route to 2-alkyl-4,5-dihydroimidazoles. 1,3-Dihalogenoalkanes afford imidazo[1,2-a]pyridines via C,N-dialkylation.

Full text of DOI:10.1016/S0040-4020(97)00752-7

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