Enhanced Enantioselectivity of the Lipase-catalyzed Hydrolysis by the Addition of a Catalytic Amount of an Amino Alcohol

Article abstract of DOI:10.1246/bcsj.64.624

L-Methioninol (L-MetOH) was discovered to be an effective additive for improving the enantioselectivity of lipase-catalyzed hydrolysis.It was found that L-MetOH accelerated the enzyme-catalyzed hydrolysis of (R)-3-acetoxybutyronitrile (1) and inhibited that of (S)-1.