The First Total Synthesis of OPC-15161

DOI: 10.1021/jo00016a012

Source and publish data:

Journal of Organic Chemistry p. 4864 - 4867 (1991)

Update date:2022-08-03

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Authors:

Ito, Yoshihiko

Sato, Hideaki

Murakami, Masahiro

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Article abstract of DOI:10.1021/jo00016a012

The first total synthesis of OPC-15161, a novel inhibitor of superoxide generation by guinea pig macrophages, has been accomplished via a convergent and efficient route exploiting the coupling of the fully functionalized pyrazine part with the indolyl gro

Full text of DOI:10.1021/jo00016a012

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Product name:3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

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