Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'

DOI: 10.1016/S0040-4039(00)79741-3

Source and publish data:

Tetrahedron Letters p. 3269 - 3272 (1991)

Update date:2022-07-29

Topics: Prodrugs ADEPT (Antibody-Directed Enzyme Prodrug Therapy) Cephalosporin Carbamate

Authors:

Alexander

Beeley Beeley

O'Driscoll

O'Neill O'Neill

Millican

Pratt Pratt

Willenbrock

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)79741-3

A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge

Full text of DOI:10.1016/S0040-4039(00)79741-3

Products guided by the article

Product name:(6R,7R)-3-{[Bis-(2-hydroxy-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Cas No:135508-70-2

R&D Labs maybe for 135508-70-2

Zhaodu Fine Chemical Plant

Contact:86-310-8067016

Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
LianYunGang Chiral Chemical(CHINA) CO.,LTD

Contact:+86-518-83616958 +86-519-82884848

Address:LianYunGang Chemical Industry Park (JiangSu)
Chengdu Yunyi International Trade Co., Ltd

Contact:0411-39894967

Address:china
Zhejiang Linhai Xinhua Chemicals Factory

Contact:0086-13661858911

Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Huludao Tianqi Shengye Chemical Co.,Ltd.

Contact:0086 429 2075777

Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China

Relevant to this article

Microwave-induced One-pot Synthesis of N-carboxyalkyl Maleimides and Phthalimides

Doi:10.1039/a707961c
(1998)
C-Glycosidic Analogues of Lipid A and Lipid X: Synthesis and Biological Activities

Doi:10.1021/jm00113a013
(1991)
Short-cut in the pomeranz-fritsch synthesis of 1-benzyl-isoquinolines; short and efficient syntheses of norrecticuline derivatives and of papaverine

Doi:10.1016/S0040-4039(00)74327-9
(1991)
Biotin-conjugated N-methylisatoic anhydride: A chemical tool for nucleic acid separation by selective 2′-hydroxyl acylation of RNA

Doi:10.1039/c4cc01134a
(2014)
Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [¹⁸F]-radiolabelling via unusual "double click" approach

Doi:10.1039/c1ob06600e
(2012)
Convenient synthesis of monobenzylated hydrazides via aqueous zinc-mediated addition reactions

Doi:10.1080/00397911.2013.851245
(2014)

Article Doi