Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'

DOI: 10.1016/S0040-4039(00)79741-3

Source and publish data:

Tetrahedron Letters p. 3269 - 3272 (1991)

Update date:2022-07-29

Topics: Prodrugs ADEPT (Antibody-Directed Enzyme Prodrug Therapy) Cephalosporin Carbamate

Authors:

Alexander

Beeley Beeley

O'Driscoll

O'Neill O'Neill

Millican

Pratt Pratt

Willenbrock

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Article abstract of DOI:10.1016/S0040-4039(00)79741-3

A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge

Full text of DOI:10.1016/S0040-4039(00)79741-3

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