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Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'

DOI: 10.1016/S0040-4039(00)79741-3

Source and publish data:

Tetrahedron Letters p. 3269 - 3272 (1991)

Update date:2022-07-29

Topics: Prodrugs   ADEPT (Antibody-Directed Enzyme Prodrug Therapy)   Cephalosporin   Carbamate  

Authors:

AlexanderAlexander

BeeleyBeeley

O'DriscollO'Driscoll

O'NeillO'Neill

MillicanMillican

PrattPratt

WillenbrockWillenbrock

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Article abstract of DOI:10.1016/S0040-4039(00)79741-3

A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge

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Full text of DOI:10.1016/S0040-4039(00)79741-3

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Product name:(6R,7R)-3-{[Bis-(2-hydroxy-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Cas No:135508-70-2

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