Tetrahedron Letters p. 3269 - 3272 (1991)
Update date:2022-07-29
Topics: Prodrugs ADEPT (Antibody-Directed Enzyme Prodrug Therapy) Cephalosporin Carbamate
Alexander
Beeley
O'Driscoll
O'Neill
Millican
Pratt
Willenbrock
A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge
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Doi:10.1039/a707961c
(1998)Doi:10.1021/jm00113a013
(1991)Doi:10.1016/S0040-4039(00)74327-9
(1991)Doi:10.1039/c4cc01134a
(2014)Doi:10.1039/c1ob06600e
(2012)Doi:10.1080/00397911.2013.851245
(2014)