Tetrahedron Letters p. 3269 - 3272 (1991)
Update date:2022-07-29
Topics: Prodrugs ADEPT (Antibody-Directed Enzyme Prodrug Therapy) Cephalosporin Carbamate Nitrogen mustard
Alexander
Beeley
O'Driscoll
O'Neill
Millican
Pratt
Willenbrock
A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge
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