REACTIONS OF FLUOROBENZENE TRICARBONYLCHROMIUM COMPLEXES WITH ANIONS FROM SCHIFF BASES OF α-AMINO ESTERS; ENANTIOSELECTIVE SYNTHESIS OF α-ARYL AMINO ACIDS

Article abstract of DOI:10.1016/S0040-4020(01)86468-1

We report here a convenient synthesis of α-substituted aryl amino acids via the addition of α-imino esters to fluorobenzene tricarbonylchromium complexes.Optically pure α-aryl amino acids have been prepared by enantioselective substitution of fluorobenzene complexes using Schiff bases of L-alanine, leucine and valine methyl esters and (1R,2R,5R)-2-hydroxypinan-3-one.