LEWIS ACID-PROMOTED DIRECT SUBSTITUTION OF 4-METHOXY- AND 4-PHENYLTHIO-2-OXAZOLIDINONES BY ALKYL CUPRATES. FACILE PREPARATION OF (3S,4S)-STATINE AND (3S,4S)-CYCLOHEXYLSTATINE.

DOI: 10.1016/0040-4039(91)80822-N

Source and publish data:

Tetrahedron Letters p. 3523 - 3526 (1991)

Update date:2022-08-03

Topics: Lewis acid Facile preparation Direct substitution

Authors:

Ishibuchi, Seigo

Ikematsu, Yumi

Ishizuka, Tadao

Kunieda, Takehisa

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Article abstract of DOI:10.1016/0040-4039(91)80822-N

Treatment of 4-methoxy- and 4-phenylthio-2-oxazolidinones with a combination of cuprates and BF3 results in smooth formation of 4-alkyl- and 4-aryl derivatives in high yield.By this method, the titled compounds of biological interest are readily synthesiz

Full text of DOI:10.1016/0040-4039(91)80822-N

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