Synthesis of (-)-(6R)- and (+)-(6S)-Tetrahydro-6--2H-pyran-2-one, lactones from Jasminum grandiflorum L. and from Polianthes tuberosa L.

Article abstract of DOI:10.1002/hlca.19910740412

(-)-(2S)-Ethyl 2-hydroxyhexanedioate ((2S)-2) was obtained by kinetic resolution of racemic ethyl 2-hydroxyhexanedioate with baker's yeast.The key intermediates (+)-(5R)- and (-)-(5S)-ethyl 5,6-epoxyhexanoate ((5R)- and (5S)-6, resp.) are proved to be use